An Efficient Targeted Drug Delivery through Apotransferrin Loaded Nanoparticles

An Efficient Targeted Drug Delivery through Apotransferrin Loaded Nanoparticles

BACKGROUND Cancerous state is a highly stimulated environment of metabolically active cells. The cells under these conditions over express selective receptors for assimilation of factors essential for growth and transformation. Such receptors would serve as potential targets for the specific ligand mediated transport of pharmaceutically active molecules. The present study demonstrates the speci...

Simultaneous diagnosis and drug delivery by silymarin-loaded magnetic nanoparticles

Objective(s): The aim of this work was to prepare and characterize magnetic nanoparticles (MNPs) as theranostic system to act simultaneously as drug carrier and MRI contrast agent. Chitosan-coated MNPs (CMNPs) were prepared and loaded with silymarin. Silymarin-loaded CMNPs were characterized with various techniques and their potential as MRI contrast agent was also evaluated. Materials and Meth...

Advances in Targeted Drug Delivery

Advances in Targeted Drug Delivery

Curcumin-Loaded Apotransferrin Nanoparticles Provide Efficient Cellular Uptake and Effectively Inhibit HIV-1 Replication In Vitro

BACKGROUND Curcumin (diferuloylmethane) shows significant activity across a wide spectrum of conditions, but its usefulness is rather limited because of its low bioavailability. Use of nanoparticle formulations to enhance curcumin bioavailability is an emerging area of research. METHODOLOGY/PRINCIPAL FINDINGS In the present study, curcumin-loaded apotransferrin nanoparticles (nano-curcumin) p...